A Comparison of Nominal Mass and High-Resolution Technologies for the Generation of Simultaneous Quantitative and Qualitative Metabolism Data
Published: 21 May 2012
Angus Nedderman, Mark Savage, Michelle Gleave and Julian Haynes
Poster Presentation, 60th ASMS Annual Conference

In recent years, the revolution in automated bioanalytical approaches has enabled the routine generation of rapid ADME data, providing key information on the metabolism of novel compounds. Amongst the most recent initiatives within the DMPK arena is a drive towards the simultaneous generation of quantitative and qualitative metabolism data, known as ‘qual/quan’ approaches. This work describes an investigation of the benefits and limitations of different mass spectrometric platforms and chromatographic approaches to the generation of qual/quan metabolism data.

Download Publication: