Understanding the Impact of Metabolism by AO and XO on Metabolite Safety and PK Predictions
Published: 03 June 2013
Michelle Gleave, Angus Nedderman, Mark Savage and Julian Haynes
Poster Presentation at DMDG Extrahepatic Metabolism Meeting, Dundee

As our understanding of cytochrome P450-mediated metabolism grows and chemical design is able to effectively modulate P450 clearance, our attention turns to other metabolising enzymes and their potential impact on clinical efficacy and safety.  Notably, aldehyde oxidase (AO) and xanthine oxidase (XO) may be potentially important contributors to drug clearance, particularly in certain areas of chemical space.  This work describes an investigation of the metabolism of precedented AO and XO substrates in a range of matrices.

Download Publication: