Enhancing Biomarker Analysis: Quantitation of Uric Acid from a Dried Blood Spot
Published: 16 May 2013
Jill Segelbacher, Julian Haynes and Angus Nedderman
Poster Presentation: DMDG/JPAG symposium: new approaches in bioanalysis and analytical technologies, London

Uric acid measurement is an important tool in the diagnosis of gout or renal disease. Allopurinol and its active metabolite oxypurinol inhibit the synthesis of uric acid by action on the enzyme xanthine oxidase.

We have developed a quantitative method for uric acid and oxypurinol in rat dried blood spots (DBS), using methyluric acid as an internal standard.

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